● `color{violet}("Enzymes")` are composed of one or several `color{violet}("polypeptide chains.")`
● However, there are a number of cases in which non-protein constituents called `color{brown}("cofactors")` are bound to the the enzyme to make the `color{violet}("enzyme catalytically active.")`
● In these instances, the protein portion of the enzymes is called the `color{brown}("apoenzyme.")`
● Three kinds of cofactors may be identified: `color{brown}("prosthetic groups, co-enzymes")` and `color{brown}("metal ions.")`
`color{green}(star "Prosthetic groups:")`
● They are `color{violet}("organic compounds")` and are distinguished from other `color{violet}("cofactors")` in that they are `color{brown}("tightly bound")` to the `color{violet}("apoenzyme. ")`
● For example, in `color{brown}("peroxidase and catalase,")` which catalyze the breakdown of `color{violet}("hydrogen peroxide")` to water and oxygen, haem is the prosthetic group and it is a part of the active site of the `color{violet}("enzyme.")`
`color{green}(star "Co-enzymes:")`
● They are also `color{violet}("organic compounds")` but their association with the apoenzyme is only `color{brown}("transient")`, usually occurring during the `color{violet}("course of catalysis.")`
● Furthermore, `color{violet}("co-enzymes")` serve as co-factors in a number of different `color{violet}("enzyme catalyzed reactions")`.
● The essential`color{violet}(" chemical components")` of many `color{violet}("coenzymes")` are `color{brown}("vitamins")`, e.g., coenzyme nicotinamide adenine dinucleotide (NAD) and NADP contain the `color{violet}("vitamin niacin.")`
`color{green}(star "Metal Ions:")`
● A number of `color{violet}("enzymes")` require metal ions for their activity which form `color{brown}("coordination bonds")` with side chains at the active site and at the same time form one or more `color{violet}("coordination bonds")` with the substrate, e.g., zinc is
a `color{violet}("cofactor")` for the `color{violet}("proteolytic enzyme carboxypeptidase.")`
● Catalytic activity is lost when the `color{violet}("co-factor")` is removed from the enzyme which testifies that they play a `color{violet}("crucial role")` in the `color{violet}("catalytic activity of the enzyme.")`
● `color{violet}("Enzymes")` are composed of one or several `color{violet}("polypeptide chains.")`
● However, there are a number of cases in which non-protein constituents called `color{brown}("cofactors")` are bound to the the enzyme to make the `color{violet}("enzyme catalytically active.")`
● In these instances, the protein portion of the enzymes is called the `color{brown}("apoenzyme.")`
● Three kinds of cofactors may be identified: `color{brown}("prosthetic groups, co-enzymes")` and `color{brown}("metal ions.")`
`color{green}(star "Prosthetic groups:")`
● They are `color{violet}("organic compounds")` and are distinguished from other `color{violet}("cofactors")` in that they are `color{brown}("tightly bound")` to the `color{violet}("apoenzyme. ")`
● For example, in `color{brown}("peroxidase and catalase,")` which catalyze the breakdown of `color{violet}("hydrogen peroxide")` to water and oxygen, haem is the prosthetic group and it is a part of the active site of the `color{violet}("enzyme.")`
`color{green}(star "Co-enzymes:")`
● They are also `color{violet}("organic compounds")` but their association with the apoenzyme is only `color{brown}("transient")`, usually occurring during the `color{violet}("course of catalysis.")`
● Furthermore, `color{violet}("co-enzymes")` serve as co-factors in a number of different `color{violet}("enzyme catalyzed reactions")`.
● The essential`color{violet}(" chemical components")` of many `color{violet}("coenzymes")` are `color{brown}("vitamins")`, e.g., coenzyme nicotinamide adenine dinucleotide (NAD) and NADP contain the `color{violet}("vitamin niacin.")`
`color{green}(star "Metal Ions:")`
● A number of `color{violet}("enzymes")` require metal ions for their activity which form `color{brown}("coordination bonds")` with side chains at the active site and at the same time form one or more `color{violet}("coordination bonds")` with the substrate, e.g., zinc is
a `color{violet}("cofactor")` for the `color{violet}("proteolytic enzyme carboxypeptidase.")`
● Catalytic activity is lost when the `color{violet}("co-factor")` is removed from the enzyme which testifies that they play a `color{violet}("crucial role")` in the `color{violet}("catalytic activity of the enzyme.")`